My research interests focus on complexity, microbial ecology, systems biology, metabolic engineering and metabolic flux analysis. In my current position at the Joint BioEnergy Institute, I am developing predictive quantitative models of microbial metabolism to direct metabolic engineering efforts and improve biofuel yields. I am also using these models and what they teach us about microbial metabolism to try and develop quantitative predictive models for microbial communities. You can find more detailed information on my research interests and the full story of how a physicist ended up working in biology here.

Education and Employment

Deputy Director, Host Engineering, Fuel Synthesis Division at the Joint BioEnergy Institute (JBEI) [2008-Present].

• Computer Project Scientist, Lawrence Berkeley National Lab [2007-Present].
• Post-doc at the Microbial Ecology Program, Joint Genome Institute [2005-2007].
• Ph. D. in theoretical condensed matter physics, University of Illinois at Urbana-Champaign [1999-2004].
  Advisor: Nigel Goldenfeld. Thesis available here.
• Licenciatura en Ciencias Fisicas, University of the Basque Country (UPV/EHU) [1994-1999].

Publications

• He, S., Kunin, V., Haynes, M., Garcia Martin , H., Ivanova, N., Rohwer, F., McMahon, H., Hugenholtz, P.
  "Metratranscriptomic array analysis of 'Candidatus Accumulibacter phosphatis'-enriched enhanced biological phosphorus removal sludge".
  Submitted
• Tang, Y.J., Garcia Martin , H., Deutschbauer, A., Feng, X., Huang, R., Llora, X., Arkin, A., Keasling, J.D. "Invariability of central metabolic flux distribution in Shewanella oneidensis MR-1 under environmental or genetic perturbations".
  In press
• Tang, Y. J., Garcia Martin , H., Myers, S., Rodriguez, S., Baidoo, E.E., Keasling, J.D.
  "Advances in analysis of microbial metabolic fluxes via (13)C isotopic labeling".
  Mass Spectrometry Reviews, 102(4):1161-9 (2009)
• Tang, Y.J., Garcia Martin , H., Dehal, P.S., Deutschbauer, A., Llora, X., Meadows, A., Arkin, A., Keasling, J.D.
  "Metabolic Flux Analysis of Shewanella spp. Reveals Evolutionary Robustness in Central Carbon Metabolism".
  Biotechnol. Bioeng. 102, 1161-1169 (2009).
• Kunin, V., He, S., Warnecke, F., Peterson, S.B., Garcia Martin, H., Haynes, M., Ivanova, N., Blackall, L.L., Breitbart, M., Rohwer, F., McMahon, K.D., Hugenholtz, P.
  "A bacterial metapopulation adapts locally to phage predation despite global dispersal".
  Genome Res., 18:293-7 (2008)
• Warnecke, F., Luginbühl, P., Ivanova, N., Ghassemian, M., Richardson, T.H., Stege, J.T., Cayouette, M., McHardy, A.C., Djordjevic, G., Aboushadi, N., Sorek, R., Tringe, S.G., Podar, M., Garcia Martin, H., Kunin, V., Dalevi, D., Madejska, J., Kirton, E., Platt, D., Szeto, E., Salamov, A., Barry, K., Mikhailova, N., Kyrpides, N.C., Matson, E.G., Ottesen, E.A., Zhang, X., Hernandez, M., Murillo, C., Acosta, L.G., Rigoutsos, I., Tamayo, G., Green, B.D., Chang, C., Rubin, E.M., Mathur, E.J., Robertson, D.E., Hugenholtz, P., Leadbetter, J.R.
  "Metagenomic and functional analysis of hindgut microbiota of a wood feeding higher termite".
  Nature, 450(7169):560-5 (2007)
• McMahon, K.D., Garcia Martin, H., Hugenholtz, P.
  "Integrating ecology into biotechnology".
  Curr. Opin. Biotechnol. 18(3):287-92 (2007)
• Marcy, Y., Ouverney, C., Bik, E.M., Lösekann, T., Ivanova, N., Garcia Martin, H., Szeto, E., Platt, D., Hugenholtz, P., Relman, D.A., Quake, S.R.
  "Dissecting biological 'dark matter' with single-cell genetic analysis of rare and uncultivated TM7 microbes from the human mouth".
  Proc. Natl. Acad. Sci. 104(29): 11889-94 (2007)
• Tang, Y.J., Chakraborty, R., Garcia Martin, H., Chu, J., Hazen, T.C., Keasling, J.D.
  "Flux analysis of central metabolic pathways in Geobacter metallireducens during reduction of soluble Fe(III)-nitrilotriacetic acid".
  Appl. Environ. Microbiol., 73(12):3859-64 (2007)
• McHardy, A. C., Garcia Martin, H., Tsirigos, A., Hugenholtz, P. and Rigoutsos, I.
  "Accurate Phylogenetic Classification of variable-length DNA fragments".
  Nat. Methods, 4(1):63-72 (2006)
• Garcia Martin, H., Ivanova, N., Kunin, V., Warnecke, F., Barry, K., McHardy, A.C., Yeates, C., He, S., Salamov, A., Szeto, E., Dalin, E., Putnam, N., Shapiro, H.J., Pangilinan, J.L., Rigoutsos, I., Kyrpides, N.C., Blackall, L.L., McMahon, K.D. and Hugenholtz, P.
  "Metagenomic analysis of phosphorus removing sludge communities"
  Nat. Biotech., 24: 1263-9 (2006)
• Markowitz, V.M., Ivanova, N., Palaniappan, K., Szeto, E., Korzeniewski, F., Lykidis, A., Anderston, I., Mavromattis, K., Kunin, V., Garcia Martin, H., Dubchack, I., Hugenholtz, P. and Kyrpides, N.C.
  "An experimental metagenome data management and analysis system"
  Bioinformatics 22(14) : e359-67 (2006)
  Garcia Martin, H. and Goldenfeld, N.
  "On the origin and robustness of power-law species-area relationships in ecology"
  Proc. Natl. Acad. Sci. USA 103(27):10310-5 (2006)
• Garcia Martin, H. and Goldenfeld, N.
  "Estimation of microbial cover distributions at Mammoth Hot Springs using a multiple clone library resampling method"
  Environ. Microbiol. 8(7):1145-54 (2006)
• Garcia Martin, H. and Goldenfeld, N
  "Linearity and scaling of a statistical model for the species abundance distribution"
  Phys. Rev. E 65 032901 (2002)

ResearcherID publication list [link]